{"id":678780,"date":"2024-07-27T08:22:03","date_gmt":"2024-07-27T07:22:03","guid":{"rendered":"https:\/\/www.thermal-engineering.org\/?p=678780"},"modified":"2024-07-27T08:22:03","modified_gmt":"2024-07-27T07:22:03","slug":"anh-huong-cua-dao-dong-nhiet-len-qua-trinh-gap-protein","status":"publish","type":"post","link":"https:\/\/www.thermal-engineering.org\/vi\/anh-huong-cua-dao-dong-nhiet-len-qua-trinh-gap-protein\/","title":{"rendered":"\u1ea2nh h\u01b0\u1edfng c\u1ee7a dao \u0111\u1ed9ng nhi\u1ec7t l\u00ean qu\u00e1 tr\u00ecnh g\u1ea5p protein"},"content":{"rendered":"<p class=\"sidekick\">\u1ea2nh h\u01b0\u1edfng c\u1ee7a dao \u0111\u1ed9ng nhi\u1ec7t l\u00ean qu\u00e1 tr\u00ecnh g\u1ea5p protein: T\u00ecm hi\u1ec3u c\u00e1ch nhi\u1ec7t \u0111\u1ed9 thay \u0111\u1ed5i t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a protein trong c\u01a1 th\u1ec3 con ng\u01b0\u1eddi.<\/p>\n<p><img src=\"https:\/\/www.thermal-engineering.org\/wp-content\/uploads\/2024\/07\/anh_huong_cua_dao_dong_nhiet_len_qua_trinh_gap_protein.png\" alt=\"\u1ea2nh h\u01b0\u1edfng c\u1ee7a dao \u0111\u1ed9ng nhi\u1ec7t l\u00ean qu\u00e1 tr\u00ecnh g\u1ea5p protein\" style=\"display: block; margin-left: auto; margin-right: auto;\"\/><\/p>\n<h2>\u1ea2nh h\u01b0\u1edfng c\u1ee7a dao \u0111\u1ed9ng nhi\u1ec7t l\u00ean qu\u00e1 tr\u00ecnh g\u1ea5p protein<\/h2>\n<p>Trong l\u0129nh v\u1ef1c sinh h\u1ecdc ph\u00e2n t\u1eed, qu\u00e1 tr\u00ecnh g\u1ea5p protein \u0111\u00f3ng m\u1ed9t vai tr\u00f2 c\u1ef1c k\u1ef3 quan tr\u1ecdng. M\u1ed9t protein \u0111\u01b0\u1ee3c g\u1ea5p \u0111\u00fang c\u00e1ch s\u1ebd c\u00f3 th\u1ec3 ho\u1ea1t \u0111\u1ed9ng m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3, trong khi m\u1ed9t protein b\u1ecb g\u1ea5p sai c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nhi\u1ec1u b\u1ec7nh l\u00fd. M\u1ed9t y\u1ebfu t\u1ed1 c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u1edbn \u0111\u1ebfn qu\u00e1 tr\u00ecnh n\u00e0y l\u00e0 dao \u0111\u1ed9ng nhi\u1ec7t.<\/p>\n<h2>Dao \u0111\u1ed9ng nhi\u1ec7t l\u00e0 g\u00ec?<\/h2>\n<p>Dao \u0111\u1ed9ng nhi\u1ec7t l\u00e0 s\u1ef1 bi\u1ebfn \u0111\u1ed5i li\u00ean t\u1ee5c c\u1ee7a nhi\u1ec7t \u0111\u1ed9 trong m\u1ed9t h\u1ec7 th\u1ed1ng. Trong c\u01a1 th\u1ec3 s\u1ed1ng, nhi\u1ec7t \u0111\u1ed9 kh\u00f4ng bao gi\u1edd tuy\u1ec7t \u0111\u1ed1i \u1ed5n \u0111\u1ecbnh m\u00e0 th\u01b0\u1eddng dao \u0111\u1ed9ng trong m\u1ed9t kho\u1ea3ng nh\u1ecf. Nh\u1eefng dao \u0111\u1ed9ng n\u00e0y c\u00f3 th\u1ec3 t\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp l\u00ean c\u1ea5u tr\u00fac c\u1ee7a protein.<\/p>\n<h2>Qu\u00e1 tr\u00ecnh g\u1ea5p protein<\/h2>\n<p>Protein l\u00e0 chu\u1ed7i d\u00e0i c\u1ee7a c\u00e1c amino acid v\u00e0 ph\u1ea3i \u0111\u01b0\u1ee3c &#8220;g\u1ea5p&#8221; theo m\u1ed9t c\u00e1ch c\u1ee5 th\u1ec3 \u0111\u1ec3 c\u00f3 th\u1ec3 ho\u1ea1t \u0111\u1ed9ng \u0111\u00fang. Qu\u00e1 tr\u00ecnh g\u1ea5p n\u00e0y th\u01b0\u1eddng \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong t\u1ebf b\u00e0o, v\u00e0 n\u00f3 b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi nhi\u1ec1u y\u1ebfu t\u1ed1 ngo\u1ea1i vi nh\u01b0 pH, n\u1ed3ng \u0111\u1ed9 ion, v\u00e0 \u0111\u1eb7c bi\u1ec7t l\u00e0 nhi\u1ec7t \u0111\u1ed9.<\/p>\n<ul>\n<li>Nhi\u1ec7t \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh gi\u00fap protein \u0111\u1ea1t \u0111\u1ebfn tr\u1ea1ng th\u00e1i g\u1ea5p \u0111\u00fang.<\/li>\n<li>S\u1ef1 thay \u0111\u1ed5i nhi\u1ec7t \u0111\u1ed9 c\u00f3 th\u1ec3 ph\u00e1 v\u1ee1 li\u00ean k\u1ebft trong protein, l\u00e0m n\u00f3 b\u1ecb bi\u1ebfn d\u1ea1ng.<\/li>\n<li>Nhi\u1ec7t \u0111\u1ed9 cao c\u00f3 th\u1ec3 l\u00e0m protein b\u1ecb &#8220;g\u1ee1&#8221; ra (denaturation).<\/li>\n<\/ul>\n<h2>\u1ea2nh h\u01b0\u1edfng c\u1ee7a dao \u0111\u1ed9ng nhi\u1ec7t<\/h2>\n<p>Dao \u0111\u1ed9ng nhi\u1ec7t c\u00f3 th\u1ec3 c\u00f3 \u1ea3nh h\u01b0\u1edfng k\u00e9p l\u00ean qu\u00e1 tr\u00ecnh g\u1ea5p protein. M\u1ed9t s\u1ed1 dao \u0111\u1ed9ng nhi\u1ec7t nh\u1ecf c\u00f3 th\u1ec3 c\u00f3 l\u1ee3i, gi\u00fap protein t\u00ecm th\u1ea5y tr\u1ea1ng th\u00e1i g\u1ea5p \u0111\u00fang b\u1eb1ng c\u00e1ch cung c\u1ea5p th\u00eam n\u0103ng l\u01b0\u1ee3ng c\u1ea7n thi\u1ebft \u0111\u1ec3 v\u01b0\u1ee3t qua c\u00e1c r\u00e0o c\u1ea3n n\u0103ng l\u01b0\u1ee3ng. Tuy nhi\u00ean, dao \u0111\u1ed9ng nhi\u1ec7t l\u1edbn ho\u1eb7c dao \u0111\u1ed9ng trong th\u1eddi gian d\u00e0i c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i.<\/p>\n<h2>H\u1eadu qu\u1ea3 c\u1ee7a dao \u0111\u1ed9ng nhi\u1ec7t kh\u00f4ng ki\u1ec3m so\u00e1t<\/h2>\n<ul>\n<li>C\u00e1c protein b\u1ecb g\u1ea5p sai c\u00f3 th\u1ec3 t\u00edch t\u1ee5 v\u00e0 h\u00ecnh th\u00e0nh c\u00e1c \u0111\u1ed1m protein kh\u00f4ng h\u00f2a tan, d\u1eabn \u0111\u1ebfn c\u00e1c b\u1ec7nh l\u00fd nh\u01b0 Alzheimer v\u00e0 Parkinson.<\/li>\n<li>Protein b\u1ecb bi\u1ebfn d\u1ea1ng c\u00f3 th\u1ec3 m\u1ea5t ch\u1ee9c n\u0103ng v\u00e0 d\u1eabn \u0111\u1ebfn c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau.<\/li>\n<\/ul>\n<h2>Qu\u1ea3n l\u00fd dao \u0111\u1ed9ng nhi\u1ec7t<\/h2>\n<p>Trong m\u00f4i tr\u01b0\u1eddng c\u00f4ng nghi\u1ec7p hay trong nghi\u00ean c\u1ee9u, vi\u1ec7c qu\u1ea3n l\u00fd nhi\u1ec7t \u0111\u1ed9 v\u00e0 dao \u0111\u1ed9ng nhi\u1ec7t l\u00e0 c\u1ef1c k\u1ef3 quan tr\u1ecdng. S\u1eed d\u1ee5ng c\u00e1c thi\u1ebft b\u1ecb ki\u1ec3m so\u00e1t nhi\u1ec7t \u0111\u1ed9 hi\u1ec7n \u0111\u1ea1i c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m thi\u1ec3u t\u00e1c \u0111\u1ed9ng ti\u00eau c\u1ef1c v\u00e0 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh g\u1ea5p protein m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3 h\u01a1n.<\/p>\n<h2>K\u1ebft lu\u1eadn<\/h2>\n<p>Dao \u0111\u1ed9ng nhi\u1ec7t l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 quan tr\u1ecdng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn qu\u00e1 tr\u00ecnh g\u1ea5p protein. Hi\u1ec3u r\u00f5 v\u00e0 ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c y\u1ebfu t\u1ed1 n\u00e0y c\u00f3 th\u1ec3 gi\u00fap t\u1ed1i \u0111a h\u00f3a hi\u1ec7u su\u1ea5t c\u1ee7a protein v\u00e0 gi\u1ea3m thi\u1ec3u nguy c\u01a1 c\u1ee7a c\u00e1c b\u1ec7nh l\u00fd li\u00ean quan \u0111\u1ebfn protein b\u1ecb g\u1ea5p sai.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u1ea2nh h\u01b0\u1edfng c\u1ee7a dao \u0111\u1ed9ng nhi\u1ec7t l\u00ean qu\u00e1 tr\u00ecnh g\u1ea5p protein: T\u00ecm hi\u1ec3u c\u00e1ch nhi\u1ec7t \u0111\u1ed9 thay \u0111\u1ed5i t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a protein trong c\u01a1 th\u1ec3 con ng\u01b0\u1eddi.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[132],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.4 - 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